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Psychiatric pathology potentially induced by COVID-19 vaccine

wchh.onlinelibrary.wiley.com

by Kris Roberts BSc, MBChB, PGCert MedEd,Nittu Sidhu MBBS, MD Psych (IND),Melanie Russel BSN, RMN,Mohammed J Abbas MBChB, M Med Sci, FRCPsych


Vaccines are the predominant biological management measure for controlling the COVID-19 pandemic, and aim to break the chain between disease status and hospitalisation. Unseen or rare side-effects are being reported via the COVID-19-specific Yellow Card reporting site, including mania, psychosis and encephalitis of various subtypes. This article presents a patient displaying a range of psychiatric pathologies that occurred within 10 days of AstraZeneca COVID-19 vaccination and resolved spontaneously without antipsychotic medication. The possibility of a vaccine-related autoimmune encephalitis (AE) is tentatively raised.

The UK Medicines and Healthcare products Regulatory Agency (MHRA) gave authorisation for the first COVID-19 vaccines in December 2020 as part of their ‘rolling review’ process that assessed the safety and efficacy of the medicines.1 As of 12 August 2021, three vaccines have been approved for UK use: the BioNTech Pfizer vaccine; the Oxford University AstraZeneca vaccine, and, most recently, the Moderna vaccine…


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