c19early: COVID-19 treatment analysis by ivmmeta.com
- Statistically significant improvements are seen for mortality, ventilation, ICU admission, hospitalization, recovery, cases, and viral clearance. All remain significant after exclusions. 53 studies from 48 independent teams in 22 different countries show statistically significant improvements in isolation (39 primary outcome, 36 most serious outcome).
- Meta analysis using the most serious outcome shows 63% [53‑72%] and 83% [74‑89%] improvement for early treatment and prophylaxis, with similar results after exclusion based sensitivity analysis, for primary outcomes, for peer-reviewed studies, and for RCTs.
- Results are very robust — in worst case exclusion sensitivity analysis 54 of 82 studies must be excluded to avoid finding statistically significant efficacy…
