Researchers who set out to examine how SARS-CoV-2, the virus responsible for COVID-19, evolved to evade the human immune system have inadvertently added fuel to the debate over whether mass vaccination may have prolonged the pandemic.
A peer-reviewed study, published this month in the journal Scientific Reports, hypothesized that SARS-CoV-2’s pathway to infecting humans shifted over time. Understanding that process will help scientists develop treatments for all future variants of the virus, the authors said.
Using public datasets consisting of blood and nasal samples from over 500 people, split into COVID-positive and control groups, the researchers found that the original strain of the SARS-CoV-2 and early variants “primarily affected pathways related to viral replication” — the process through which viruses insert their genetic material into host cells, co-opting those cells to create new viral particles…
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