Children's Health Defense A new review shows that chemicals used to replace BPA may disrupt reproductive health in much the same way as the original additive. These “safe” substitutes are used in plastics, processed food, children’s toys and paper receipts. Experts warn that the alternatives were introduced without proper testing and could pose long-term risks.
By Pamela Ferdinand
Chemicals increasingly used to replace the toxic plastic additive bisphenol A (BPA) may disrupt fertility, fetal development and reproductive health through many of the same biological mechanisms, according to a narrative review of human, animal and laboratory studies.
Concerns about BPA have led some manufacturers to phase it out and replace it with structurally similar compounds, most commonly bisphenol S (BPS), bisphenol F (BPF) and bisphenol AF (BPAF). While BPA exposure has declined, BPS and BPF use are rising, especially in North America and Asia.
The review, published this month in Archives of Medical Research, found that these BPA substitutes — widely used in plastics, processed food and food packaging, children’s toys and paper receipts — can interfere with the same hormone systems and gene-regulation pathways that control reproductive development in both males and females.
“Although these compounds were originally synthesized to be safe for human use, they have also exhibited endocrine-disrupting activity similar to BPA, which affects reproductive function,” the researchers wrote.
“These changes can lead to reproductive disorders and negative long-term and transgenerational consequences.”
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